He emigrated to the U.S.A. on April 11, 1844, and took a job with his uncle David Ranken, a tea importer. By July of 1849 he had started his own business as an importer of general groceries. He became a U. S. Citizen on October 8, 1852. He was made a Mason in Union Lodge No. 121 in Philadelphia on June 13, 1861, and served as Worshipful Master in 1867.

He married Miss Ellen Hunt Graham of Tazewell Tennessee, who was a confederate Army sympathizer. They were married at the West Spruce Street Presbyterian Church in Philadelphia on April 2, 1868. His only son, Thomas Graham Patton, was born on March 21, 1869. His wife died just 6 days later, on March 27th. At the age of 7, after an attack of scarlet fever, followed by diabetes, his son died. Less than two years later the heartbroken Mr. Patton sold his grocery business to retire, but became active in the investment of his wealth, and in Masonic circles.

He was elected in 1873 and served as Grand Treasurer of the Grand Lodge for 34 consecutive years, until his death.

Brother William J. Kelly, R. W. Past Grand Master, donated Egyptian Hall at the Masonic Temple in Philadelphia in honor of his friend, Thomas Ranken Patton.
His Royal Highness, The Prince of Wales, appointed Brother Patton the Representative of the Grand Lodge of England to the Grand Lodge of Pennsylvania, the first such appointment ever made by the Grand Lodge of England.

During his lifetime he was described by R. W. Past Grand Master Michael Arnold as "a courtly gentleman of polite and dignified manner, tall and erect, commanding respect by his presence." On December 27, 1889, he donated to the Grand Lodge the sum of $25,000 to create the Thomas Ranken Patton Memorial Charity Fund, in memory of his late wife, to be used for "the relief of poor but respectable widows" of Pennsylvania Masons. He later added the sum of $125,000 to the fund. Patton's example established a precedent that was followed by several other well-to-do Masons of his time.

In December 1900, the Grand Lodge elected him an Honorary Member, an honor only conferred before that time upon Brother George Washington and Brother the Marquis de LaFayette.

He died in Philadelphia on September 13, 1907, and his formal portrait was immediately thereafter commissioned, as it was a custom, to that time, not to hang portraits of living Grand Lodge officers in the Masonic Temple. It was presented to the Grand Lodge in 1908. His extensive estate consisted of shrewd stock and real estate investments, and more than half of it, valued at approximately $1,040,000 after taxes, was give to the Grand Lodge for the establishment of a boarding school for male orphan children of Master Masons, in memory of his son, Thomas. It would later be established as the Thomas Ranken Patton Masonic Institution for Boys.

On October 6, 1923 the cornerstone of Patton Hall was laid, and the school opened in January of 1925 with an enrollment of 14 students. The main educational building, Memorial Hall, opened in September 1926 and included the machine, carpenter and brick shops and the classrooms. A second dormitory, Ranken Hall, was opened in 1928. The school was dedicated, in Patton's words, to "...the development of capable industrious and honest men" and for 50-years it provided vocational, moral and religious training to all students.

Closed in 1977 due to lack of enrollment, the Grand Lodge subsequently approved the renovation and conversion of the facility into the Masonic Conference Center--Patton Campus which is the headquarters and center of operation of the Pennsylvania Youth Foundation, which was established with a purpose consistent with the aims of Brother Patton, to realize more fully the potential of youth. We pay a tribute of gratitude and reverence to the memory of Thomas Ranken Patton for both his generosity and foresight to extend Freemasonry's charity toward youth.